Medicinal plant is new Horizones in Spinocerebellar ataxia

 

Narendra B. Patil*1, Ketan B. Patil2, Sandip S. Kshirsagar3

1Department of Pharmacology, Dr. A.P.J. Abdul Kalam University, Indore.

2Department of Pharmaceutices, Ahinsa Institute of Pharmacy, Dondaicha (Maharashtra)

3Department of Pharmaceutices, Ali Allana Colleage of Pharmacy, Akkalkuwa

*Corresponding Author E-mail: pnarendra101@gmail.com

 

ABSTRACT:

Spinocerebellar ataxia (SCA) are large complex group of heterogeneous autosomal dominant Neurodegenerative disorders characterised by cerebellar dysfunction caused by expanded CAG repeats encoding a long polyglutamine (PolyQ) stretch have been shown to cauae dominating inherited SCA1, SCA2, SCA3, SCA6, SCA7, SCA17. the medicinal plants and their extract for treatment and management of Spinocerebellar ataxia Paeonia lactiflora, Gardenia jasminoides were are reported. The article reviews is an attempt to compile and documented information on different aspect of medicinal plant with potent for treat to Spinocerebellar ataxia.

 

KEYWORDS: Neurodegenerative disease, Spinocerebellar ataxia, G. jasminoides, P. lactiflora.

 

 

 

INTRODUCTION:

Spinocerebellar ataxia(SCA's) are a large, complex group of heterogenous autosomal dominant neurodengeneartive disorders characterised by cerebellar dysfunction alone or in combination with other neurological abnormalities.1 the expansions of CAG trinucleotide repeats encoding a polyglutamide (poly Q) stretch have beenshown to cauae dominating inherited SCA 1, SCA2, SCA3, SCA 6, SCA7, SCA 17.2 These poly Q mediated genetic disorders in SCAs have been shown selectively progressive degeneration of the cerebellum, brainstem and spinal tract with prominant pathological hallmark of intranuclear and cytoplasmic accumulation of agregated ploy Q proteins inside degenerated neurons3. The aggregated poly Q proteins may cause dysfunction of mitochondria, chaperone leading apoptosis and cell death4-6.

 

Increasing evidence suggests that some herbs may potentially attenuate the deterioration of neurodegenerative disease. Paeonia lactiflora belonging to the Paeoniaceae family.7 Paeoniflorin one of the main compounds extracted from P. lactiflora has been reported ameliorate neurodegenerative process in treating SCA, Parkinsons disease and Alzheimers disease8

 

Gardenia jasminoides has utilised as an oriental folk medicine for treatment of SCA3 as antioxidanta. Geniposide one of the main compounds extracted from G. jasminoides has shown the neuroprotective effect by up-regulating the antioxidative capacity9.

 

Herbs used in treatment of SCA:

1) Gardenia jasminoides:

Gardenia jasminoids or jasmin is an evergreen flowering plant of the coffee family Rubiaceae.it originated in Asia and is most commonly found growing wild in Vietnam, Southern China, Korea, Taiwan, Japan, India.

 

Taxonomical Classification:

Kingdom-Plantae

Division-Angiosperms

Class-Eudicots

Sub class-Asterids

Order-Gentianals

Family-Rubiaceae

Genus-Gardenia

Species-G. jasminoides

Binomial name-Gardenia jasminoides

 

 

Fig.no.1 Gardenia jasminoids plant.

 

Phytoconstituent of G. jasminoides:

Geniposide one of the main compounds extracted from G. jasminoides and their derivatives like genipin, crosin having neuroprotective effect.

 

Uses of G. jasminoides:

Gardenia jasminoides has been utilised for the treatments of edema, fever, and hepatic disorder. Geniposide one of the main compounds extracted from G.jasminoides has shown neuroprotective effect by up regulating the antioxidative capacity.as the accumulation of misfolded poly Q protein ia likely the initial event in the pathogenic cascade can be suppressed by antioxidants, it is possible that G.jasminoides and its derivatives may play a role 8n treating SCA as antioxidants.

 

2) Paeonia lactiflora:

Paenoia lactiflora or garden peony is a species of herbaceous perennial flowering plant in the family Paeoniaceae, native to central and Eastern Asia from Eastern Tibet across northern china to Eastern Siberia.

 

Taxonomical classification:

Kingdom-Plantae

Division-Angiosperms

Class-Eudicots

Order-Saxifragales

Family-Paeoniaceae

Genus-Paeonia

Species-P. lactiflora

Binomial name-Paeonia lactiflora

 

 

Fig.no.2 Paeonia lactiflora

Phytoconstituent in P. lactiflora:

Paoeniflorin one of the main compounds extracted from P. lactiflora has been reported ameliorate neurodegenerative process activity8.

 

Uses of P. lactifloria:

Paeonflorin is reported to ameliorate neurodegenerative process in treatment of parkinsons disease, Alzheimer disease and SCA.8

It has commonly used for nourishing blood, alleviating pain, treating liver disease. (7)

 

CONCLUSION:

The review might to useful to supplement information in regards the plants used in treatments of Spinocerebellar ataxia. This article also motivates researchers and helps them during a screening of this medicinal plants.

 

CONFLICT OF INTREST:

None

 

REFERENCE:

1.      A. Matilla-Duenas, M. Corral, V. Volpini, the Spinocerebellar ataxia -clinical aspects and molecular genetics, Advances in experimental medicine and Biology, 2012, 724, 351-374.

2.      H.T. Orr, M.Y. Chung, S. Banfi, Expansion of an unstable trinucleotideCAG repeat in Spinocerebellar ataxia, Nature Genetics, 1996, 14(3), 269-276.

3.      H.Y. Zoghbi and H.T. Orr, polyglutamine disease: protein cleavage and aggregation, current opinion in Neurobiology, 1999, 9(5), 566-570.

4.      A. Solans, A. Zambrano, M. Rodriguez, Cytotoxicity of a mutant huntingtin fragment in yeast involves early alternations in mitochondrial OXPHOS Complexes II and III, Human molecular Genetics, 2006, 15(20), 3063-3081.

5.      E.J. Bennett, T.A. Shaler, B. Woodman, Global changes to the ubiquitin system in Huntingtons disease, Nature, 458(7154), 2007, 704-708.

6.      S.M. Chafekar and M.L. Duennwald, Impaired heat shock response in cells expressing full length polyglutamine expanded huntingetin, PLOSONE, 7(5), 2012, 37929.

7.      T.T. Ou, C.H. Wu, C.J. Wang, Paeomia lactiflora pall inhibits bladder cancer growth involving phosphorylation of chk2 invitro and invivo, Journal of Ethnopharmacology, 135(1), 2011, 162-172.

8.      Kuo-Husan Chang, Wan -Ling Chen, Chiung-Mei chen, Aqueous extract of paeonia lactflora and paeoniflorin as aggregation reducers targeting chaperones in cell models of Spinocerebellar ataxia 3, Evidence Based complementary and alternative medicine, 471659 1-11.

9.      Kuo-Hsuan, Yih-Ru-Wu, Li-Ching Lee, Aqueous extract of gardenia jasminoides targeting oxidative stress to reduce poly Q aggregation in cell models of Spinocerebellar ataxia 3, Neuropharmacology, 81, 166-175, 2014.

 

 

Received on 07.11.2019         Modified on 30.12.2019

Accepted on 21.01.2020      ©Asian Pharma Press All Right Reserved

Asian J. Pharm. Res. 2020; 10(1): 29-30.

DOI: 10.5958/2231-5691.2020.00006.4